Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Biotin

Generic name
Biotin
Brand name
ATC Code
A11HA05

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Holocarboxylase deficiency
  • Intravenous
    • 0 years up to 18 years
      [1]
      • 10 - 40 mg/day in 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with using biotin for this indication.

    • 0 years up to 18 years
      • 10 - 40 mg/day in 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with using biotin for this indication.

    • 0 years up to 18 years
      • 10 - 40 mg/day in 3 doses.
      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with using biotin for this indication.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Sodium benzoate for tackling secondary hyperammonaemia is contraindicated in organic acid disorders. Patients with organic acid disorders have a tendency to develop hypokalaemia. Potassium levels must only be corrected if there is diuresis.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Reference

  1. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases., Springer, 2006

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Changes

Changes