- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
There is no information about the pharmacokinetic parameters for sodium benzoate in children.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Hyperammoniaemia |
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| Maintenance treatment for hyperammonaemia as a result of urea cycle defects |
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Nausea, vomiting, metabolic acidosis.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Not for organic acid disorders. Depending on the plasma concentration if possible. A properly running infusion is needed because of necrosis in the event of extravasation. Nausea: give a strong antiemetic beforehand. Watch out for hypernatraemia.
The taste of oral sodium benzoate is very unpleasant, so taking it at mealtimes is difficult. It should therefore preferably be taken immediately after a meal.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| OTHER DIAGNOSTIC AGENTS | ||
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| V04C | ||
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References
- Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases., Springer, 2006
- Batshaw ML, Inborn errors of urea synthesis, Ann Neurol, 1994, Feb;35(2), 133-41
- Enns GM, et all, Survival after treatment with phenylacetate and benzoate for urea-cycle disorders, N Engl J Med, 2007, May 31;356(22), 2282-92
- Praphanphoj V, et al, Three cases of intravenous sodium benzoate and sodium phenylacetate toxicity occurring in the treatment of acute hyperammonaemia, J Inherit Metab Dis, 2000, Mar;23(2), 129-36
- Ucyclyd Pharma, Inc.,, FDA Label Ammonul, http://www.accessdata.fda.gov
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Changes
Changes
