- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Tuberculosis, actual or suspected tuberculous meningitis/miliary TBC/joint or bone TBC |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Hepatotoxicity and neuropathies.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Regular checks of the hepatic function are recommended. Adding 20 mg pyridoxine once daily to the isoniazid for preventing neuropathy is only needed in children who are being breast-fed and in adolescents and children with an insufficient diet. Watch out for convulsions.
TDM (plasma) is feasible in patients with polyneuropathies and/or heptic impairment:
T=0: <0,5 mg/l
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antibiotics | ||
|---|---|---|
| J04AB02 | ||
| Other drugs for treatment of tuberculosis | ||
|---|---|---|
| J04AK05 | ||
| J04AK06 | ||
| J04AK02 | ||
| J04AK01 | ||
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References
- Hartwig NC, et al, Vademecum pediatrische antimicrobiële therapie, 2005
- NVALT, Richtlijn Medicamenteuze behandeling van tuberculose, www.nvalt.nl, 2014
- Pharmachemie BV, SPC Isoniazide (RVG 52072), www.cbg-meb.nl, Geraadpleegd 14 juli 2010, http://db.cbg-meb.nl/IB-teksten/h52072.pdf
- RIEMSER, SmPC ISOZID® 200 mg, Tabletten (6192548.02.00), 10/2015
- RIEMSER, SmPC ISOZID® 100 mg, Tabletten (6192548.01.00), 10/2015
- Online GL. Gelbe Liste Online, https://www.gelbe-liste.de/, Accessed June 4, 2018
- RIEMSER, SmPC ISOZID 0,5 N, Pulver zur Herstellung einer Infusionslösung (6192577.00.00), 10/2018
- RIEMSER, SmPC ISOZID® 50 mg, Tabletten (6192548.00.00), 10/2015
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Changes
Changes
