Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Phenethicillin

Generic name
Phenethicillin
Brand name
ATC Code
J01CE05

Pharmacokinetics in children

No pharmacokinetic studies have been carried out in children.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Non-severe infections
  • Oral
    • 0 years up to 2 years
      • 62.5 mg/dose 3x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.
Moderately severe infections
  • Oral
    • 2 years up to 10 years
      • 250 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • ≥ 10 years
      • 500 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 1 month up to 2 years
      • 125 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • Term neonate
      • 125 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 1 month up to 2 years
      [3]
      • 125 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 2 years up to 10 years
      [3]
      • 250 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • ≥ 10 years
      [3]
      • 500 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • Term neonate
      [3]
      • 125 mg/dose 3-6x daily.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.
Secondary prophylaxis for group A streptococci in patients with acute rheumatism
  • Oral
    • < 28 kg
      • 250 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • ≥ 28 kg
      • 500 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • < 28 kg
      [4]
      • 250 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • ≥ 28 kg
      [4]
      • 500 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.
Prophylaxis for infection in sickle cell anaemia/asplenia
  • Oral
    • 4 months up to 12 months
      • 15 mg/kg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 1 year up to 5 years
      • 250 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 5 years up to 12 years
      • Prophylaxis is only indicated in relevant comorbidities or when on-demand antibiotic treatment is not feasible. 500 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

    • 12 years up to 18 years
      • Prophylaxis is only indicated in relevant comorbidities and when on-demand antibioitic treatment is not feasible. 500 mg/day in 2 doses.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.
Prophylaxis for Streptococcus viridans infection in the treatment of AML with high doses of cytarabine
  • Oral
    • 1 month up to 18 years
      • 50 mg/kg/day in 3 doses. Max: 1.500 mg/day.
      • Directions for administration:

        Should preferably be taken 1 hour before or 2 hours after a meal.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Hypersensitivity reactions such as exanthema, purpura and urticaria. Nausea, vomiting, diarrhoea, hyperkalaemia.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications in children

The suspension should not be used in children with phenylketonuria because it contains aspartame or with fructose intolerance because of the presence of sorbitol.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

The syrup should not be used in children with phenylketonuria because it contains aspartame. High doses of penicillin can create abnormalities in the blood count.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Penicillins with extended spectrum
J01CA04
J01CA01
J01CA11
J01CA08
Beta-lactamase sensitive penicillins
J01CE08
J01CE01
J01CE02
J01CE10
Beta-lactamase resistant penicillins
J01CF01
J01CF05
J01CF02
J01CF02
Combinations of penicillins, incl. beta-lactamase inhibitors
J01CR02
J01CR01, J01CR04
J01CR05
J01CR04

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References

  1. Hartwig NC, et al, Vademecum pediatrische antimicrobiële therapie, 2005
  2. Heijboer H, et al, NVK Tweede herziene leidraad Acute en chronische behandeling van kinderen met sikkelcelziekte., www.nvk.nl, mei 2014, https://www.nvk.nl/Portals/0/richtlijnen/sikkelziekte/leidraad%20sikkelcelziekte%20definitief%20mei%202014.pdf
  3. ACE Pharmaceuticals BV, SmPC Broxil (RVG 04959) 18-14-2013, www.cbg-meb.nl
  4. NVK, Werkboek Kinderreumatologie, 2014
  5. Landelijk Centrum Infectieziekten (LCI), Richtlijn Groep A streptokokkeninfectie (GAS), www.rivm.nl, 2016, Juli
  6. SKION, Werkboek Supportive care. H2, www.skion.nl, December 2017
  7. RIVM, Richtlijn Asplenie, www.lci.rivm.nl, 2018

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Changes

Changes