No information
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| Bacterial infections |
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| Severe bacterial infections |
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| Infection in cystic fibrosis |
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| Early localized, disseminated and late Lyme disease |
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| Prophylaxis after a tick bite |
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| Treatment of uncomplicated malaria |
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| Prophylaxis for malaria |
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GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
(irreversible) tooth discoloration in children, disorders of dental development
Recent observational studies indicate that doxycycine treatment of small children does not seem to induce permananent tooth discoloration [Todd 2015, Biggs 2016, Poyhonen 2017, Volovitz 2007]. Therefore, doxycycline - which binds less to calcium than tetracycline - can be considered in younger children (< 8 years) when alternative treatment options are lacking.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Use in children <8 years, because of the risk of damage to growing bone and dental tissue and irreversible discoloration (yellow / gray / brown) of the teeth, unless the condition is very serious and there is no other treatment option; with facial rosacea <12 years;
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Permanent discoloration of developing teeth: With use of tetracyclines during the second half of pregnancy or in children up to and including 8 years of age, enamel hypoplasia and permanent discoloration (yellow-gray-brown) of the teeth have been reported. This side effect is more common with long-term use of tetracyclines, but has also been reported after repeated short-term use. Use of doxycycline in children <8 years of age is contraindicated, except in severe or life-threatening conditions (eg 'Rocky Mountain spotted fever'), especially when there is no other treatment option. Consider use in children 8–12 years only if other drugs are ineffective, contraindicated or unavailable.
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The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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