- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Oncological conditions |
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Convulsions, often with hypertension and in a few cases followed by coma, paralytic ileus (particularly in young children), hepato-occlusive conditions
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Extravasation: Inject hyaluronidase into the area immediately. Cover the site of the extravasation with warm compresses. Consult the cosmetic surgeon.
General cytostatic agents: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Vinca alkaloids and analogues | ||
|---|---|---|
| L01CA01 | ||
| Podophyllotoxin derivatives | ||
|---|---|---|
| L01CB01 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Pharmachemie BV, SPC Vincristinesulfaat PCH (RVG 10956), www.cbg-meb.nl, Geraadpleegd 28 mei 2010, http://db.cbg-meb.nl/IB-teksten/h10956.pdf
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Changes
Changes
