- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
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Dosages
| Oncological conditions |
|---|
|
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Renal impaiment in children > 3 months
At a creatinine clearance of > 50 ml/min/1.73m²:
Dose adjustment is not required
At a creatinine clearance of 10-50 ml/min
Reduce the initial dose to 75% of the standard dose, then dose depending on clinical effect and tolerance by the patient
At a creatinine clearance of less than 10 ml/min:
no generalized recommendations are given
Information
The clearance of etoposide is less when the renal function is reduced. The risk of side effects is elevated as a result.
Clinical consequences:
The key dose-related side effects are bone marrow depression (above all leukopenia), gastrointestinal problem and stomatitis.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Extravasation:Severe reactions are not to be expected.
Check the infusion for precipitates.
General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Vinca alkaloids and analogues | ||
|---|---|---|
| L01CA01 | ||
| L01CA02 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Pharmachemie B.V., SmPC Toposin (RVG 16010) dd 04-10-2017, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
