- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Oncological conditions |
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Extravasation: apply cold compresses immediately, for at least 6 hours. Repeat this for 1 week, 4 times daily for 20 minutes. In serious cases, wound excision may be required.
The urine may be coloured red.
General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.
Children are more susceptible to myocardial damage; they should be subject to long-term cardiological follow-up. Hypokalaemia also increases cardiotoxicity.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Anthracyclines and related substances | ||
|---|---|---|
| L01DB01 | ||
| Other cytotoxic antibiotics | ||
|---|---|---|
| L01DC01 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Sanofi-Aventis Netherlands BV, SPC Cerubidine (RVG 05633), www.cbg-meb.nl, Geraadpleegd 26 jan 2012, http://db.cbg-meb.nl/IB-teksten/h05633.pdf
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Changes
Changes
