Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Cytarabine

Generic name
Cytarabine
Brand name
ATC Code
L01BC01

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Oncological conditions
  • Intravenous
    • 0 years up to 18 years

      • The dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.

        The following indicative dosages have been stated by the manufacturer:
        Induction remission: 100-200 mg/m²/day intravenous, maintenance of remission 75-200 mg/m².
        Intrathecal: 5-75 mg/m²/dose, mostly 30 mg/m², once every 4 days
        High dosages: 2-3 g/m² IV twice daily, for 2-6 days, total treatment dose max 35 g/m²

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Extravasation: Severe reactions are not to be expected.

General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Purine analogues
L01BB02
L01BB03

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. EBEWE Pharma Ges.m.b.H. Nfg. KG, SPC Alexan (RVG 06468), www.cbg-meb.nl, Geraadpleegd 27 mei 2010, http://db.cbg-meb.nl/IB-teksten/h06468.pdf
  3. Sandoz b.v., SmPC (RVG 06468) 20-11-2017, www.geneesmiddeleninformatiebank.nl

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Changes

Changes