Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Dantrolene (oral)

Generic name
Dantrolene (oral)
Brand name
ATC Code
M03CA01

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Muscle spasms
  • Oral
    • 1 month up to 18 years
      • Initial dose: 0.5 mg/kg/day in 1 dose
      • Maintenance dose: Increase weekly if necessary by 0.5-1 mg/kg/day to 0.5 - 8 mg/kg/day in 3 - 4 doses. Max: 12mg/kg/day, but not exceeding 400 mg/day.
      • The usual maintenance dose is 3-8 mg/kg/day

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Drowsiness, tiredness, weakness. Less commonly diarrhoea. Hepatotoxicity has been described after prolonged use.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Check the hepatic function.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Dantrolene and derivatives
M03CA01

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Norgine BV, SmPC Dantrium (RVG 06978) 2-11-2018, www.geneesmiddeleninformatiebank.nl

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Changes

Changes