Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Cocaine

Generic name
Cocaine
Brand name
ATC Code
N01BC01

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Topical anaesthesia for ENT procedures
  • Mucosal
    • 1 month up to 18 years
      • Apply cocaine at a maximum concentration of 4% to the mucous membranes.  Maximum dose: 3 mg/kg (max 200 mg) per procedure

         

      • No studies have been conducted into the use of cocaine in children for surgical ENT interventions.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Exclusively for topical anaesthesia for surgical ENT procedures. If necessary in combination with adrenaline 1:20,000

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Reference

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2008

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Changes

Changes