- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Available formulations
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Dosages
| Constipation |
|---|
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Abdominal pain, abdominal cramps. Severe rashes and blisters may form in the perianal area if small children ingest such amounts that diarrhea occurs. The risk of this side effect is higher in children who are not yet toilet trained.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Long-term use is not recommended due to permanent damage to colon mucosa, such as melanosis coli. Another risk is the occurrence of irreversible damage to the bowel myenteric plexus, which can negatively affect motility. This risk arises especially with long-term use, so it is recommended to limit the use to a maximum of 5 days.
Few studies have been conducted into the effectiveness and side effects of the "other laxatives", including senna. Since they are rarely used in practice and due to the lack of evidence, these products are not recommended as the first choice.
X-Praep syrup contains alcohol.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
| Osmotically acting laxatives | ||
|---|---|---|
| A06AD11 | ||
| Enemas | ||
|---|---|---|
| A06AG | ||
| A06AG10 | ||
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
References
- Mylan Healthcare B.V, SmPC Sennocol (RVG 03184) 14 okt 2019, www.geneesmiddeleninformatiebank.nl
- NVK, Richtlijn Obstipatie bij kinderen van 0-18 jaar, www.nvk.nl, 2015
- Spiller HA et al, Skin breakdown and blisters from senna-containing laxatives in young children, Ann Pharmacother, 2003, May;37(5), 636-9
- Mylan Healthcare B.V, SmPc X-praep (RVG 07207) 20 mrt 2019, www.geneesmiddeleninformatiebank.nl
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Changes
Changes
