Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Atovaquone

Generic name
Atovaquone
Brand name
ATC Code
P01AX06

Pharmacokinetics in children

T½ 2-3 days. Lipophilicity. Food increases the uptake by a factor of 2-3. Lower absorption in children younger than 2 years.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Prophylaxis for pneumonia caused by Pneumocystis jirovecii (PCP)
  • Oral
    • 1 month up to 3 months
      • 30 mg/kg/day in 1 dose
    • 3 months up to 2 years
      • 45 mg/kg/day in 1 dose
    • ≥ 2 years
      • 30 mg/kg/day in 1 dose. Max: 1.500 mg/day.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Hydroxyquinoline derivatives
P01AA02
Nitroimidazole derivatives
P01AB01

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Reference

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor kinderen, 2007

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Changes

Changes