- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No studies have been carried out into the pharmacokinetic parameters of cutaneous tretinoin in children.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Plantar verruca |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Mild skin irritation, in particular at the start of the treatment (burning sensation, erythema, itching, dryness, flaky skin)
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Higher concentrations give more side effects. The tolerability of tretinoin is affected by the delivery method (alcohol or cream). The chemical stability of tretinoin is affected by light, which is why it should be applied in the evening before going to sleep.
Starting with a low concentration, lower frequency of administration and shorter contact duration can improve the tolerability.
Tretinoin is highly teratogenic. Insufficient details are known about cutaneous use during pregnancy. Cases of congenital abnormalities have been reported. Cutaneous application during pregnancy is therefore not recommended.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Retinoids for topical use in acne | ||
|---|---|---|
| D10AD03 | ||
| D10AD53 | ||
| Peroxides | ||
|---|---|---|
| D10AE01 | ||
| Antiinfectives for treatment of acne | ||
|---|---|---|
| D10AF51 | ||
| D10AF01 | ||
| D10AF02 | ||
| D10AF51 | ||
| Other anti-acne preparations for topical use | ||
|---|---|---|
| D10AX03 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Eichenfield LF, et al, Study of the efficacy and tolerability of 0.04% tretinoin microsphere gel for preadolescent acne, Pediatrics, 2010, Jun;125(6), e1316-23.
- Webster G, et al, A combined analysis of 2 randomized clinical studies of tretinoin gel 0.05% for the treatment of acne, Cutis, 2009, Mar;83(3), 146-54
- Eichenfield LF, et al, Perspectives on therapeutic options for acne: an update, Semin Cutan Med Surg, 2010, Jun;29(2 Suppl 1), 13-6
- Zaenglein AL, , Expert committee recommendations for acne management.. , Pediatrics, 2006, Sep;118(3), 1188-99
- Gollnick H, et al, Global Alliance to Improve Outcomes in Acne.Management of acne: a report from a Global Alliance to Improve Outcomes in Acne, J Am Acad Dermatol, 2003, Jul;49(1 Suppl), S1-37
- Bruinsma M, et al, NHG Standaard Acne (derde herziening), Huisarts Wet, 2017 (april)
- Zaenglein AL,, Expert committee recommendations for acne management.., Pediatrics, 2006, Sep;118(3), 1188-99
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Changes
Changes
