Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Rizatriptan

Generic name
Rizatriptan
Brand name
ATC Code
N02CC04

Pharmacokinetics in children

No kinetic studies have been carried out in children.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Migraine: acute treatment during headache phase
  • Oral
    • 6 years up to 18 years and < 40 kg
      • 5 mg/dose, once only.
    • 6 years up to 18 years and ≥ 40 kg
      • 10 mg/dose, once only.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Risk of cardiovascular conditions including myocardial infarction.
Dizziness, dry mouth, nausea, sleepiness, asthenia.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Selective serotonin (5HT1) agonists
N02CC01
N02CC03
Other antimigraine preparations
N02CX01

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References

  1. Ahonen K et al, A randomized trial of rizatriptan in migraine attacks in children, Neurology, 2006, 67, 1135-40
  2. Visser WH, et al, Rizatriptan 5 mg for the acute treatment of migraine in adolescents: results from a double-blind, single-attack study and two open-label, multiple-attack studies, Headache, 2004, Oct;44(9), 891-9
  3. Winner P, et al, Rizatriptan 5 mg for the acute treatment of migraine in adolescents: a randomized, double-blind, placebo-controlled study, Headache, 2002, Jan;42(1), 49-55

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Changes

Changes