Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Urapidil

Generic name
Urapidil
Brand name
ATC Code
C02CA06

Pharmacokinetics in children

No specific information in children available.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Hypertensive crisis
  • Intravenous
    • 1 month up to 18 years
      • Initial dose: 2 mg/kg/hour, continuous infusion. Titrate dose on effect.
      • Maintenance dose: 0.8 mg/kg/hour, continuous infusion.
        • Lower initial doses (max 1 mg/kg/h) may be sufficient in infants (expert opinion)
        • When sufficient decrease in bloodpressure is obtained, a lower maintenance dose may be sufficient to maintain the effect.
        • Limited experience is available in children.
        • Due to the amount of propylenglycole the use in children < 5 years should be avoided. Other antihypertensive drugs are preferred and the use in children should be limited to the last resort  and shortest duration. 

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Formulations contain propylenglycol. Maximum intake for different age groups have to be taken into account.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Schöber, Pilossoff et al., Urapidil therapy for acute hypertensive crisis in infants and children, 1984
  2. Nordic Group B.V., SmPC Urapidil Nordic 50 mg/10 ml, oplossing voor injectie (RVG 120483//101895), 07/2022, www.geneesmiddeleninformatiebank.nl

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Changes

Changes