Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Cefepim

Generic name
Cefepim
Brand name
ATC Code
J01DE01

Pharmacokinetics in children

2 months to 16 years:

Cl: 3,3 ml/min/kg
Vd: 0,3 l/kg
T1/2: 1,7 hour

[SmPC Cefepim]

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Very serious bacterial infections including febrile neutropenia
  • Intravenous
    • 1 month up to 2 months
      • 90 mg/kg/day in 3 doses.
    • 2 months up to 18 years
      • 150 mg/kg/day in 3 doses. Max: 6 g/day.
    • 1 month up to 2 months
      [2]
      • 90 mg/kg/day in 3 doses.
    • 2 months up to 18 years
      [1]
      • 150 mg/kg/day in 3 doses. Max: 6 g/day.

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Renal impaiment in children > 3 months

Children 2 months up to 40 kg

Creatinine clearance
(ml/min.) 		Serious infections Very serious infections, febrile neutropenia
> 50 No dose adjustment required No dose adjustment required
30 -50 Normal single dose (50 mg/kg/dose), dosing interval 24 hours Normal single dose (50 mg/kg/dose), dosing interval 12 hours
11-29 Half of normal single dose halveren (25 mg/kg/dose), dosing interval 24 hours Normal single dose (50 mg/kg/dose), dosing interval 24 hours
≤ 10 Quarter of normal single dose (12,5 mg/kg/dose), dosing interval 24 hours Half of normal single dose  (25 mg/kg/dose), dosing interval 24 hours

Infants 1-2 months

Creatinine clearance
(ml/min.) 		Serious infections Very serious infections, febrile neutropenia
> 50 No dose adjustment required No dose adjustment required
30 -50 Normal single dose (30 mg/kg/dose), dosing interval 24 hours Normal single dose (30 mg/kg/dose), dosing interval 12 hours
11-29 Half of normal single dose halveren (15 mg/kg/dose), dosing interval 24 hours Normal single dose (30 mg/kg/dose), dosing interval 24 hours
≤ 10 Quarter of normal single dose (7,5 mg/kg/dose), dosing interval 24 hours Half of normal single dose  (15 mg/kg/dose), dosing interval 24 hours

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

The safety profile of cefepim in infants and children is similar to that in adults with that in adults.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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First-generation cephalosporins
J01DB05
J01DB04
J01DB01
J01DB03
Second-generation cephalosporins
J01DC04
J01DC03
J01DC02
Third-generation cephalosporins
J01DD08
J01DD01
J01DD13
J01DD52
J01DD02
J01DD14
J01DD04
Monobactams
J01DF01
Carbapenems
J01DH03
J01DH51
J01DH02
MONOBACTAMS
J01DF01
Other cephalosporins and penems
J01DI02

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References

  1. Fresenius Kabi Nederland bv, SmPC Cefepim (RVG 102543) 21-11-2018, www.geneesmiddeleninformatiebank.nl
  2. Stragen Pharma GmbH, SmPC Cefepim Stragen 1 g Powder for injection (94391.00.00), 09/2020

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Changes

Changes