Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Medroxyprogesteron (oraal)

Generic name
Medroxyprogesteron (oraal)
Brand name
ATC Code
G03DA02

Pharmacokinetics in children

No information on use in children.

 

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Prevention of endometrial hyperplasia in oestrogen treatment for puberty induction or growth inhibition
  • Oral
    • ≥ 12 years
      • (medroxyprogesteronacetate) 5 - 10 mg/day in 1 dose
      • Duration of treatment:

        During the first 10-14 days of the month.

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Renal impaiment in children > 3 months

Caution is needed in acute kidney impairment, as medroxyprogesterone may cause moderate fluid retention.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Noordam C et al,, Werkboek Kinderendocrinologie, digitale publicatie op www.nvk.nl (alleen leden), 2010
  2. NKFK Workinggroup Acute Kidney Impairment, Extrapolation of KNMP risk analysis "Impaired renal function" for adults to children, 20 Dec 2021
  3. Pozo J., Ascertainment and treatment of delayed puberty., Horm Res, 2003, 60 Suppl 3:, 35-48
  4. Normann EK., Height reduction in 539 tall girls treated with three different dosages of ethinyloestradiol., Arch Dis Child., 1991, 66(11), 1275-8
  5. Grüters A., Effect of different oestrogen doses on final height reduction in girls with constitutional tall stature., Eur J Pediatr., 1989, 149(1), 11-3
  6. Drop SL, Sex steroid treatment of constitutionally tall stature, Endocr Rev., 1998, 19(5), 540-58
  7. Matthews D., Hormone supplementation for pubertal induction in girls., Arch Dis Child, 2017, 102(10), 975-80
  8. de Waal WJ., [Hormonal therapy of constitutionally tall children], Ned Tijdschr Geneeskd, 1998, 142(13), 693-7

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Changes

Changes