Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Solifenacine

Generic name
Solifenacine
Brand name
ATC Code
G04BD08

Pharmacokinetics in children

The pharmacokinetic parameters in children (2-18 years) in which the dose was adjusted for bodyweight was comparable to that in adults after correction for body weight. [SmPC]

Vd  8,6 l/kg
T1/2 45-68 hour
Tmax 4-12 hour
Cl 9,5 l/hour

 

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Available formulations

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Dosages

Overactivity of the neurogenic detrusor
  • Oral
    • 2 years up to 18 years and 9 up to 16 kg
      • 2 mg/day in 1 dose. Max: 4 mg/day.
    • 2 years up to 18 years and 16 up to 31 kg
      • 3 mg/day in 1 dose. Max: 5 mg/day.
    • 2 years up to 18 years and 31 up to 46 kg
      • 3 mg/day in 1 dose. Max: 6 mg/day.
    • 2 years up to 18 years and 46 up to 61 kg
      • 4 mg/day in 1 dose. Max: 8 mg/day.
    • 2 years up to 18 years and ≥ 61 kg
      • 5 mg/day in 1 dose. Max: 10 mg/day.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Renal impaiment in children > 3 months

  • Creatinineklaring > 30 ml/min:  Dose adjustment not needed
  • Creatinineklaring < 30 ml/min: do not exceed the starting dose once day. Cautious treatment is indicated

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

In general, the safety profile in children is comparable to that of adults. The following side effects were observed in children: dry mouth, constipation (especially at maximum dose), abdominal pain, drowsiness, urinary tract infection and prolonged QT interval.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

The suspension Vesicare contains propyleenglycol 20 mg/ml and ethanol 10 mg/ml

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Reference

  1. Astellas Pharma Europe B.V, SmPC Vesicare (RVG 116539) 18-10-2019, www.geneesmiddeleninformatiebank.nl

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Changes

Changes