- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information is present at this moment.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Clostridium difficile infection |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
The safety profile is expected to be similar to that of adults, although incidental urticaria has also been reported in children.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Children <1 year: Testing for C. difficile colonization or the toxin is not recommended in children <1 year due to common asymptomatic colonization, unless severe diarrhea in infants with risk factors for stasis, such as Hirschsprung's disease, operated on anal atresia or other serious bowel motility disorders. C. difficile enterocolitis must be demonstrated in this population, and always look for an alternative medical cause.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antibiotics | ||
|---|---|---|
| A07AA07 | ||
| A07AA01 | ||
| A07AA02 | ||
| A07AA06 | ||
| A07AA11 | ||
| A07AA09 | ||
| Imidazole derivatives | ||
|---|---|---|
| A07AC01 | ||
| ANTIBIOTICS | ||
|---|---|---|
| A07AA07 | ||
| A07AA01 | ||
| A07AA02 | ||
| A07AA06 | ||
| A07AA11 | ||
| A07AA09 | ||
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Reference
- Astellas Pharma, SmPC Dififlir EU 1/11/733 22-08-2016 susp: 5-12-2011, www.geneesmiddelinformatiebank.nl
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Changes
Changes
