Fomepizole

Generic name
Fomepizole
Brand name
ATC Code
VO3AB34
Compare …

Fomepizole

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Acute ethylene glycol intoxication
  • Intravenous
    • 1 month up to 18 years

      • Start:15 mg/kg/dose

        Subsequent doses:
        second dose (12 hours after starting): 10 mg/kg/dose
        third dose (24 hours after starting): 10 mg/kg/dose
        fourth dose (36 hours after starting): 10 mg/kg/dose
        fifth dose (48 hours after starting): 7.5–15 mg/kg/dose
        sixth dose (60 hours after starting): 5-15 mg/kg/dose
        Administer over 30-45 minutes.

        Until the ethylene glycol levels have dropped to below 0.2 g/l (3.2 mmol/l).
        The number of maintenance doses and the dosage after 48 hours will depend on the initial concentration and the progression of the ethylene glycol levels over time. In general, 4 to 5 maintenance doses are recommended for initial ethylene glycol levels of between 3 and 6 g/l (48 to 96 mmol/l) and 1 to 3 maintenance doses are recommended for initial ethylene glycol levels of between 0.35 and 1.5 g/l (5.6 to 24 mmol/l)
methanol or ethylene glycol intoxication
  • Intravenous
    • 1 month up to 18 years

      • Start: 15 mg/kg/dose

        Subsequent doses:
        second dose (12 hours after starting): 10 mg/kg/dose
        third dose (24 hours after starting): 10 mg/kg/dose
        fourth dose (36 hours after starting): 10 mg/kg/dose
        fifth dose (48 hours after starting): 7.5–15 mg/kg/dose
        sixth dose (60 hours after starting): 5-15 mg/kg/dose
        Administer over 30-45 minutes.

        Until the methanol or ethylene glycol levels have dropped to below 0.2 g/l (3.2 mmol/l).
        The number of maintenance doses and the dosage after 48 hours will depend on the initial concentration and the progression of the methanol or ethylene glycol levels over time. In general, 4 to 5 maintenance doses are recommended for initial methanol or ethylene glycol levels of between 3 and 6 g/l (48 to 96 mmol/l) and 1 to 3 maintenance doses are recommended for initial methanol or ethylene glycol levels of between 0.35 and 1.5 g/l (5.6 to 24 mmol/l)

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

References

  1. Eusa Pharma, SPC Fomepizole (RVG 26970) 21/07/11, www.cbg-meb.nl, Geraadpleegd 23 okt 2014
  2. SERB, SmPC Fomepizole (RVG 26970) 20-05-2019, www.geneesmiddelinformatiebank.nl
  3. Nederlandse Vereniging van Ziekenhuisapothekers / Nationaal Vergiftigingen Informatie Centrum / Nederlandse Vereniging voor Klinische Farmacologie & Biofarmacie (NVKF&B), Monografie methanol, https://toxicologie.org/methanol/, 14 juli 2022, Versie 3

Changes

Therapeutic Drug Monitoring


Overdose