Zinc sulphate

Generic name
Zinc sulphate
Brand name
ATC Code
A12CB01
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Zinc sulphate

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Wilson’s disease
  • Oral
    • ≥ 18 years
      • 600 mg/day in 3 doses.
        • Titrate the dose depending on free copper in the serum and copper excretion in the urine. Range 300-1200 mg/day in 3 doses. 
        • Do not administer concomitantly with D-penicillamine. 
        • If this upsets the stomach, an equivalent amount of zinc can alternatively be given as zinc gluconate.
Deficiency
  • Intravenous
    • 1 month up to 18 years

      • Dose according to the plasma concentrations.

      • No clinical studies have been carried out into the use of zinc sulphate in children
Maintenance requirement for zinc in TPN
  • Intravenous
    • 2 up to 15 kg
      • 250 microg./kg/day in Peditrace.

      • No clinical studies have been carried out into the use of zinc sulphate in children on TPN.

    • ≥ 15 kg
      • 3.8 mg/day in Peditrace.

      • No clinical studies have been carried out into the use of zinc sulphate in children on TPN.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Requirements of trace elements in children in particular are only known approximately. Supplementation of trace elements is needed when total parenteral nutrition is indicated.

 

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER MINERAL SUPPLEMENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Sodium
A12CA01
Magnesium
A12CC05
A12CC01
A12CC04
A12CC03
A12CC02
Selenium
A12CE02
Other mineral products
A12CX
MAGNESIUM
A12CC05
A12CC01
A12CC04
A12CC03
A12CC02
OTHER MINERAL PRODUCTS
A12CX

Reference

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007

Changes

Therapeutic Drug Monitoring


Overdose