Alfacalcidol

Generic name
Alfacalcidol
Brand name
ATC Code
A11CC03
Compare …

Alfacalcidol

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Osteodystrophy, secondary hyperparathyroidism in chronic renal disease stage 5 (dialysis patients)
  • Intravenous
    • 1 month up to 18 years
      • After the dialysis 0.58 - 3.47 microg./m²/week, bolus. Max: 6.93 microg./m²/week.
Rachitis (rickets)
  • Oral
    • 1 month up to 18 years
      • 0.25 - 0.5 microg./day in 1 dose. Max: 2 microg./day.
    • 1 month up to 18 years
      • 0.25 - 0.5 microg./day in 1 dose. Max: 2 microg./day.
Chronic hypocalcaemia
  • Oral
    • Term neonate
      • 0.04 - 0.08 microg./kg/day in 1 dose

      • Titrate the dose depending on the effect.

    • 1 month up to 18 years
      [1] [3]
      • 0.25 - 0.5 microg./day in 1 dose. Max: 2 microg./day.

      • Titrate the dose depending on the effect.

    • 1 month up to 18 years
      • 0.25 - 0.5 microg./day in 1 dose. Max: 2 microg./day.

      • Titrate the dose depending on the effect.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Watch out for hypercalcaemia.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vitamin A, plain
A11CA01
Vitamin D and analogues
A11CC04
A11CC05

References

  1. Pharmachemie BV, SPC Alfacalcidol (RVG 10890), www.cbg-meb.nl, Geraadpleegd 11 aug 2010, http://db.cbg-meb.nl/IB-teksten/h10890.pdf
  2. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  3. Leo Pharma BV, SPC Etalpha (RVG 07603), www.cbg-meb.nl, Geraadpleegd 26 mei 2010, http://db.cbg-meb.nl/IB-teksten/h07603.pdf

Changes

Therapeutic Drug Monitoring


Overdose