Adenosine

Generic name
Adenosine
Brand name
ATC Code
C01EB10
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information is present at this moment.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Supraventricular tachycardia
  • Intravenous
    • Term neonate

      • Initial dose: 100 microg/kg/dose, IV push

        • If 1e dose is not effective: 200 microg/kg/dose
        • If 2e dosis is not effective: 300 microg/kg/dosis
        • A consecutive dose can be administered 1-2 minutes after the previous dose.
        • There is no point increasing the dose if the arrhythmia stops but reappears immediately.
    • 1 month up to 18 years

      • Initial dose: 100 microg/kg/dose, max 6 mg/dose, IV push

        • If 1st dose is not effective: 200 microg/kg/dose, max 12 mg/dose
        • If 2nd dose is not effective: 300 microg/kg/dose, max 12 mg/dose
        • If 3rd dose is not effective: consider 500 microg/kg/dose, max 12 mg/dose
        • A consecutive dose can be administered 1-2 minutes after the previous dose.
        • There is no point increasing the dose if the arrhythmia stops but reappears immediately.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Flushing, bouts of shortness of breath and the induction of ventricular tachycardia.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Must be administered with ECG checks. Adenosine has no negative inotropic and vasodilating properties. Should be injected quickly. Because of the possible induction of ventricular tachycardia, a defibrillator should be kept on standby.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER CARDIAC PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Prostaglandins
C01EA01
Other cardiac preparations
C01EB06
C01EB16

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Genzyme Europe B.V., SPC Adenocor (RVG 16617) 04-12-2020, www.geneesmiddeleninformatiebank.nl
  3. Turner N, et al, Advanced Pediatric Life Support - de Nederlandse editie, Reed Business, 2017, 407-17

Changes

Therapeutic Drug Monitoring


Overdose