Dantrolene (oral)

Generic name
Dantrolene (oral)
Brand name
ATC Code
M03CA01
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Dantrolene (oral)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Muscle spasms
  • Oral
    • 1 month up to 18 years
      • Initial dose: 0.5 mg/kg/day in 1 dose
      • Maintenance dose: Increase weekly if necessary by 0.5-1 mg/kg/day to 0.5 - 8 mg/kg/day in 3 - 4 doses. Max: 12mg/kg/day, but not exceeding 400 mg/day.

      • The usual maintenance dose is 3-8 mg/kg/day

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Drowsiness, tiredness, weakness. Less commonly diarrhoea. Hepatotoxicity has been described after prolonged use.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Check the hepatic function.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Dantrolene and derivatives
M03CA01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Norgine BV, SmPC Dantrium (RVG 06978) 2-11-2018, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose