Physostigmine

Generic name
Physostigmine
Brand name
ATC Code
V03AB19

Physostigmine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Atropine intoxication
  • Intravenous
    • 1 month up to 18 years
      • Physostigmine salicylate 0.02 mg/kg/dose, bolus in 5 min,. Max: 0.5 mg/dose. Repeat every 10 minutes if necessary up to a maximum cumulative dose of 2 mg/day.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Watch out for bronchoconstriction. Keep atropine to hand in case of an overdose of physostigmine.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ALL OTHER THERAPEUTIC PRODUCTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Antidotes
V03AB27
V03AB16
V03AB24
V03AB25
V03AB33
V03AB17
V03AB15
V03AB13
V03AB14
V03AB06
V03AB35
Iron chelating agents
V03AC03
V03AC02
V03AC01
Drugs for treatment of hyperkalemia and hyperphosphatemia
V03AE07
V03AE01
V03AE02
V03AE01
Detoxifying agents for antineoplastic treatment
V03AF03
V03AF01
V03AF07
Drugs for treatment of hypoglycemia
V03AH01
Other therapeutic products
V03AX03
DETOXIFYING AGENTS FOR ANTINEOPLASTIC TREATMENT
V03AF03
V03AF01
V03AF07
OTHER THERAPEUTIC PRODUCTS
V03AX03

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Dr. Franz Köhler Chemie GmHB, SmPC Anticholium (6073341.00.00) , 03-2022
  3. Dr. Franz Köhler Chemie GmHB, SmPC Anticholium (6073341.00.00), 03-2022
  4. Shenoi RP et al., COMMITTEE ON DRUGS; COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE: Drugs Used to Treat Pediatric Emergencies, Pediatrics, 2020, Jan;145(1), e20193450

Changes

Therapeutic Drug Monitoring


Overdose