Fentanyl, nasal

Generic name
Fentanyl, nasal
Brand name
ATC Code
N02AB03
Compare …

Fentanyl, nasal

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No data known on use in children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Acute pain
  • Nasal
    • 6 months up to 18 years
      • 1 - 2 microg./kg/dose, as required repeat. Max single dose: 100 microg./dose.
Palliative care
  • Nasal
    • 0 years up to 18 years
      • 0.5 - 2 microg./kg/dose, as required repeat. Max single dose: 100 microg./dose.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Intranasale toepassing leidt snel tot afhankelijkheid. Let op bij langdurig gebruik.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OPIOIDS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Natural opium alkaloids
N02AA03
N02AA01
N02AA05
N02AA59
Phenylpiperidine derivatives
N02AB03
N02AB02
Diphenylpropylamine derivatives
N02AC06
N02AC03
Oripavine derivatives
N02AE01
Morphinan derivatives
N02AF02
Other opioids
N02AX06
N02AX01
N02AX02
Opioids in combination with non-opioid analgesics
N02AJ13

References

  1. Hansen MS et al., Limited evidence for intranasal fentanyl in the emergency department and the prehospital setting--a systematic review, Dan Med J, 2013, Jan;60(1), A4563
  2. Harlos MS et al, Intranasal fentanyl in the palliative care of newborns and infants, J Pain Symptom Manage, 2013, Aug;46(2), 265-74
  3. Herd D et al., Intranasal fentanyl paediatric clinical practice guidelines, Emerg Med Australas, 2009, Aug;21(4), 335
  4. Mudd S et al, Intranasal fentanyl for pain management in children: a systematic review of the literature., J Pediatr Health Care, 2011, Sep-Oct;25(5), 316-22
  5. Pieper L et al., Intranasal fentanyl for respiratory distress in children and adolescents with life-limiting conditions, BMC Palliat Care, 2018, Sep 10;17(1), 106

Changes

Therapeutic Drug Monitoring


Overdose