Tiopronin

Generic name
Tiopronin
Brand name
ATC Code
G04BX16
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Cystinuria
  • Oral
    • ≥ 9 years
      • Initial dose: 15 mg/kg/day in 3 doses.
      • Maintenance dose: If necessary raise it depending on the effect to a maximum of 50 mg/kg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders/nephrologist) who has experience with using tiopronin for this indication.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Hypersensitivity, glomerulotubulopathy, abnormal blood counts.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Be aware of the possibility of hypersensitivity, glomerulotubulopathy or abnormal blood counts.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

UROLOGICALS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Acidifiers
G04BA01
Drugs for urinary frequency and incontinence
G04BD04
G04BD04
G04BD06
G04BD08
G04BD07
G04BD09
Drugs used in erectile dysfunction
G04BE03
G04BE08

Reference

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007

Changes

Therapeutic Drug Monitoring


Overdose