Saccharomyces boulardii

Generic name
Saccharomyces boulardii
Brand name
ATC Code
A07FA02
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Saccharomyces boulardii

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Saccharomyces boulardii gets not destroyed by gastric acid and is not absorbed.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Acute diarrhea
  • Oral
    • 6 months up to 18 years
      • 250 mg/dose 1-2 times daily. In acute gastroenteritis up to 250 mg/dose 3 times daily..
      • Directions for administration:
        • The capsules can be opened and sprinkled over food or dissolved in water
        • In case of tube feed-induced diarrhoea, give the contents of 2 hard capsules (= 500 mg) per litre or 750 mg in 1.5 l of nutrient solution daily.

      •  
Prophylaxis of diarrhea
  • Oral
    • 2 years up to 18 years
      • 250 - 500 mg/day in 1 - 2 doses.

      • Traveler's diarrhea: start 5 days before departure

    • 2 years up to 18 years
      [3] [4]
      • 250 - 500 mg/day in 1 - 2 doses.

      • Traveler's diarrhea: start 5 days before departure

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Patients suffering diarrhea, especially children, should consider replacing fluids and salts (electrolytes) as the most important treatment option.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIDIARRHEAL MICROORGANISMS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

References

  1. Ardeypharm, SmPC Yomogi Kps. (1-23695), 01/2018
  2. Szajewska H, et al, Use of Probiotics for the Management of Acute Gastroenteritis in Children: An Update. 2020 , J Pediatr Gastroenterol Nutr. , 2020, Aug;71(2), 261-9
  3. Szajewska H, et al., Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children., J Pediatr Gastroenterol Nutr., 2016, MAr;62(3), 495-506
  4. Ardeypharm GmbH, SmPC Yomogi 250 mg (89086.00.00), 12/2017
  5. Szajewska H, et al, Use of Probiotics for the Management of Acute Gastroenteritis in Children: An Update. 2020, J Pediatr Gastroenterol Nutr., 2020, Aug;71(2), 261-9

Changes

Therapeutic Drug Monitoring


Overdose