Trometamol

Generic name
Trometamol
Brand name
ATC Code
B05BB03
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Trometamol

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information available about the pharmacokinetic parameters in children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Severe metabolic acidosis combined with respiratory acidosis. Metabolic acidosis in neonates, infants and children with hypernatraemia
  • Intravenous
    • 0 years up to 18 years

      • Number of ml trometamol (0.3M) = base deficit (mmol/l) x weight (kg) x 0.5 in 30-60 minutes.
        Repeat if necessary. This is the theoretical value for a half correction of the base deficit.

        Maximum dose: Maximum 500 mg/kg/dose = 13.9 ml/kg/dose. .

        The quantity of trometamol needed for complete correction of the base deficit is:
        Number of ml trometamol (0.3M) = bodyweight (kg) x base deficit (mmol/l) x 1.1

         

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications in children

It is also contraindicated in neonates in salicylate intoxication.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

The solution with a pH of 10-11 gives severe problems on extravasation (tissue necrosis). This must not be administered in peripheral vessels and in the vessels of the umbilical cord. Use the solution with pH 8.6.

 

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

I.V. SOLUTIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Solutions affecting the electrolyte balance
B05BB01
B05BB01
Solutions producing osmotic diuresis
B05BC01

References

  1. Heijman JA, et al, Toepassing en risico’s van trometamol. Complicatie: weefselnecrose, Pharmaceutisch weekblad, 2002, Jan; 137(3), 90-93
  2. Nahas GG, et al, Guidelines for the treatment of acidaemia with THAM, Drugs, 1998, Feb;55(2), 191-224
  3. Hospira, FDA Label Tham Solution, 2005, www.accesdata.fda.gov

Changes

Therapeutic Drug Monitoring


Overdose