Pharmacokinetics in children
No information is present at this moment.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Prevention of flares from generalized pustular psoriasis (GPP) |
- Subcutaneous
-
12 years
up to
18 years
and
≥ 40 kg
- Initial dose:
Loading dose:
600
mg/dose,
once only.
- Maintenance dose:
300
mg/dose
once every 4 weeks.
-
12 years
up to
18 years
and
30
up to
40 kg
- Initial dose:
Loading dose:
300
mg/dose,
once only.
- Maintenance dose:
150
mg/dose
once every 4 weeks.
|
| Flares of generalized pustular psoriasis (GPP) |
- Intravenous
-
12 years
up to
18 years
and
≥ 40 kg
-
12 years
up to
18 years
and
30
up to
40 kg
|
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
IMMUNOSUPPRESSANTS
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Selective immunosuppressants |
|
|
|
L04AA24
|
|
|
|
L04AA32
|
|
|
|
L04AA13
|
|
|
|
L04AA02
|
|
|
|
L04AA06
|
|
|
|
L04AA31
|
|
|
|
L04AA04
|
|
|
|
L04AA44
|
| Other immunosuppressants |
|
|
|
L04AX01
|
|
|
|
L04AX03
|
| Tumor necrosis factor alpha (TNF-alpha) inhibitors |
|
|
|
L04AB04
|
|
|
|
L04AB01
|
|
|
|
L04AB06
|
|
|
|
L04AB02
|
| Interleukin inhibitors |
|
|
|
L04AC03
|
|
|
|
L04AC02
|
|
|
|
L04AC08
|
|
|
|
L04AC13
|
|
|
|
L04AC19
|
|
|
|
L04AC10
|
|
|
|
L04AC07
|
|
|
|
L04AC05
|
| Calcineurin inhibitors |
|
|
|
L04AD01
|
|
|
|
L04AD02
|
| Sphingosine-1-phosphate (S1P) receptor modulators |
|
|
|
L04AE01
|
| Janus-associated kinase (JAK) inhibitors |
|
|
|
L04AF02
|
|
|
|
L04AF02
|
|
|
|
L04AF08
|
|
|
|
L04AF01
|
| Monoclonal antibodies |
|
|
|
L04AG04
|
| Mammalian target of rapamycin (mTOR) kinase inhibitors |
|
|
|
L04AH02
|
|
|
|
L04AH01
|
| Complement inhibitors |
|
|
|
L04AJ01
|
|
|
|
L04AJ02
|
| Dihydroorotate dehydrogenase (DHODH) inhibitors |
|
|
|
L04AK02
|
Reference
-
Boehringer Ingelheim International GmbH, SmPC Spevigo EU/1/22/1688/001 Rev 1, 10-10-2024, www.geneesmiddelinformatiebank.nl
Therapeutic Drug Monitoring
Overdose