Ziprasidon

Generic name
Ziprasidon
Brand name
ATC Code
N05AE04
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Ziprasidon

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Taking into account the difference in body weight, the pharmacokinetics of ziprasidone in paediatric patients aged 10 to 17 years were comparable to those in adult patients.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Bipolar disorder
  • Oral
    • 10 years up to 18 years and < 45 kg
      • Initial dose: On day 1: 20 mg/day in 1 dose
      • Maintenance dose: increase initial dose as needed based on effect in 1-2 weeks to 40 - 80 mg/day in 2 doses. Max: 80 mg/day.
      • Directions for administration:

        Take with food.

    • 10 years up to 18 years and ≥ 45 kg
      • Initial dose: On day 1: 20 mg/day in 1 dose
      • Maintenance dose: increase the initial dose as needed based on effect in 1-2 weeks to 40 - 160 mg/day in 2 doses. Max: 160 mg/day.
      • Directions for administration:

        Take with food.

      • The usual effective maintenance dose is between 80 and 160 mg.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

In children with bipolar disorder (10 to 17 years): very common (≥ 10%): sedation, drowsiness, headache, fatigue, nausea, and dizziness

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Ziprasidone is associated with a dose-related prolongation of the QT interval. Do not exceed the maximum dose.

An unequal distribution of the daily dose with morning doses 20 mg or 40 mg lower than evening doses can be considered.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIPSYCHOTICS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Phenothiazines with aliphatic side-chain
N05AA02
Butyrophenone derivatives
N05AD01
N05AD05
Indole derivatives
N05AE05
Diphenylbutylpiperidine derivatives
N05AG02
Diazepines, oxazepines, thiazepines and oxepines
N05AH02
N05AH03
N05AH04
Lithium
N05AN01
Other antipsychotics
N05AX12
N05AX13
N05AX08

References

Changes

Therapeutic Drug Monitoring


Overdose