Cefepim

Generic name
Cefepim
Brand name
ATC Code
J01DE01
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

2 months to 16 years:

Cl: 3,3 ml/min/kg
Vd: 0,3 l/kg
T1/2: 1,7 hour

[SmPC Cefepim]

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Very serious bacterial infections including febrile neutropenia
  • Intravenous
    • 1 month up to 2 months
      • 90 mg/kg/day in 3 doses.
    • 2 months up to 18 years
      • 150 mg/kg/day in 3 doses. Max: 6 g/day.
    • 1 month up to 2 months
      [2]
      • 90 mg/kg/day in 3 doses.
    • 2 months up to 18 years
      [1]
      • 150 mg/kg/day in 3 doses. Max: 6 g/day.

Renal impaiment in children > 3 months

Children 2 months up to 40 kg

Creatinine clearance
(ml/min.) 		Serious infections Very serious infections, febrile neutropenia
> 50 No dose adjustment required No dose adjustment required
30 -50 Normal single dose (50 mg/kg/dose), dosing interval 24 hours Normal single dose (50 mg/kg/dose), dosing interval 12 hours
11-29 Half of normal single dose halveren (25 mg/kg/dose), dosing interval 24 hours Normal single dose (50 mg/kg/dose), dosing interval 24 hours
≤ 10 Quarter of normal single dose (12,5 mg/kg/dose), dosing interval 24 hours Half of normal single dose  (25 mg/kg/dose), dosing interval 24 hours

Infants 1-2 months

Creatinine clearance
(ml/min.) 		Serious infections Very serious infections, febrile neutropenia
> 50 No dose adjustment required No dose adjustment required
30 -50 Normal single dose (30 mg/kg/dose), dosing interval 24 hours Normal single dose (30 mg/kg/dose), dosing interval 12 hours
11-29 Half of normal single dose halveren (15 mg/kg/dose), dosing interval 24 hours Normal single dose (30 mg/kg/dose), dosing interval 24 hours
≤ 10 Quarter of normal single dose (7,5 mg/kg/dose), dosing interval 24 hours Half of normal single dose  (15 mg/kg/dose), dosing interval 24 hours

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

The safety profile of cefepim in infants and children is similar to that in adults with that in adults.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER BETA-LACTAM ANTIBACTERIALS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

First-generation cephalosporins
J01DB05
J01DB04
J01DB01
J01DB03
Second-generation cephalosporins
J01DC04
J01DC03
J01DC02
Third-generation cephalosporins
J01DD08
J01DD01
J01DD13
J01DD52
J01DD02
J01DD14
J01DD04
Monobactams
J01DF01
Carbapenems
J01DH03
J01DH51
J01DH02
MONOBACTAMS
J01DF01
Other cephalosporins and penems
J01DI02

References

  1. Fresenius Kabi Nederland bv, SmPC Cefepim (RVG 102543) 21-11-2018, www.geneesmiddeleninformatiebank.nl
  2. Stragen Pharma GmbH, SmPC Cefepim Stragen 1 g Powder for injection (94391.00.00), 09/2020

Changes

Therapeutic Drug Monitoring


Overdose