L-arginine

Generic name
L-arginine
Brand name
ATC Code
B05XB01
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L-arginine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Transient hyperammoniaemia in a neonate
  • Intravenous
    • Term neonate

      • Dose in consultation with a metabolic disorders paediatrician.
Hyperammoniaemia
  • Intravenous
    • 0 years up to 18 years
      [3] [4] [5] [6]
      • Initial dose: 350 mg/kg/dose, once only in 90 minutes.
      • Maintenance dose: 350 - 700 mg/kg/day, continuous infusion.
        • Ornithine transcarbamoylase (OTC) and carbamoyl phosphate synthetase (CPS) deficiency: up to 150 mg/kg/day
        • Argininosuccinate synthetase and argininosuccinate lyase deficiency: up to 700 mg/kg/day

        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with arginine for this indication.

         

    • 0 years up to 18 years
      • Initial dose: 350 mg/kg/dose, once only in 90 minutes.
      • Maintenance dose: 350 - 700 mg/kg/day, continuous infusion.
        • Ornithine transcarbamoylase (OTC) and carbamoyl phosphate synthetase (CPS) deficiency: up to 150 mg/kg/day
        • Argininosuccinate synthetase and argininosuccinate lyase deficiency: up to 700 mg/kg/day

        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with arginine for this indication.

         

    • 0 years up to 18 years
      • Initial dose: 350 mg/kg/dose, once only in 90 minutes.
      • Maintenance dose: 350 - 700 mg/kg/day, continuous infusion.
        • Ornithine transcarbamoylase (OTC) and carbamoyl phosphate synthetase (CPS) deficiency: up to 150 mg/kg/day
        • Argininosuccinate synthetase and argininosuccinate lyase deficiency: up to 700 mg/kg/day

        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience with arginine for this indication.

         
Growth hormone secretion test
  • Intravenous
    • 1 month up to 18 years
      • Arginine chloride, 10%: 0.5 g/kg/dose, once only. Max single dose: 30 g/dose. run in over 30 min..

      • A properly running infusion is needed because of necrosis in the event of extravasation.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

A properly running infusion is needed because of necrosis in the event of extravasation.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

I.V. SOLUTION ADDITIVES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Electrolyte solutions
B05XA07
B05XA19
B05XA14
B05XA31
B05XA06
Vitamins
B05XC
VITAMINS
B05XC

References

  1. Rademaker C.M.A. et al., Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Noordam C et al, Werkboek Kinderendocrinologie, digitale publicatie op www.nvk.nl (alleen leden), 2010
  3. Volwassenen, Kinderen en Stofwisselingziekten, Zorgpad Arginosuccinaat Lyase Deficientie (ASLD), http://www.stofwisselingsziekten.nl, Okt 2012, http://www.stofwisselingsziekten.nl/ziekte_informatie/zorgpaden_voor_stofwisselingsziekten
  4. Volwassenen, Kinderen en Stofwisselingziekten, Zorgpad Arginosuccinaat Synthetase Deficientie (ASSD), http://www.stofwisselingsziekten.nl/, Okt 2012, http://www.stofwisselingsziekten.nl/ziekte_informatie/zorgpaden_voor_stofwisselingsziekten
  5. Volwassenen, Kinderen en Stofwisselingziekten, Zorgpad Carbamoyl Fosfaat Synthetase 1 Deficientie (CPS1D), http://www.stofwisselingsziekten.nl/, Okt 2012, http://www.stofwisselingsziekten.nl/ziekte_informatie/zorgpaden_voor_stofwisselingsziekten
  6. Volwassenen, Kinderen en Stofwisselingziekten, Zorgpad Ornithine Transcarbamoylase Deficientie (OTCD), http://www.stofwisselingsziekten.nl/, Okt 2012, http://www.stofwisselingsziekten.nl/ziekte_informatie/zorgpaden_voor_stofwisselingsziekten

Changes

Therapeutic Drug Monitoring


Overdose