Tocopherol acetate DL-alpha (vitamin E)

Generic name
Tocopherol acetate DL-alpha (vitamin E)
Brand name
ATC Code
A11HA03
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Tocopherol acetate DL-alpha (vitamin E)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Supplementation in cystic fibrosis
  • Oral
    • 1 month up to 1 year
      • 50 IU/day in 1 - 3 doses.
Deficiency
  • Oral
    • 1 month up to 18 years
      • 5 - 10 mg/kg/day in 2 doses. Max: 300 mg/day.

      • Vitamin E should preferably be administered in a water-soluble form.

    • 1 month up to 18 years
      [2]
      • 5 - 10 mg/kg/day in 2 doses. Max: 300 mg/day.

      • Vitamin E should preferably be administered in a water-soluble form.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Necrotizing enterocolitis has been reported in children with low birthweights who received a high dose (200 mg tocopherol acetate daily) as a hyperosmolar solution.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER PLAIN VITAMIN PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Other plain vitamin preparations
A11HA05
A11HA01
A11HA06
A11HA02
A11HA04
A11HA08

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Kneepkens CMF et al, Werkboek Kindergastro-Enterologie, VU Uitgeverij, 2002, 2e druk
  3. Turck D, et al., ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis, Clinical Nutrition, 2016, 35, 557-77

Changes

Therapeutic Drug Monitoring


Overdose