Pyridoxalphospate

Generic name
Pyridoxalphospate
Brand name
ATC Code
A11HA06
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Pyridoxalphospate

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No data available

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Pyridoxine-dependent epilepsy
  • Oral
    • 0 years up to 18 years
      • Initial dose: 10 mg/kg/day in 1 dose
      • Maintenance dose: When effect is lacking within 24 hours, increase the dose to: 30 - 50 mg/kg/day in 4 - 6 doses.

      • Treatment by of after consultation of paediatric specialist who has experience in using pyridoxalphosphate for this indication.
        CAVE: When switching from pyridoxine to pyridoxal phosphate, pyridoxine should be discontinued.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Apnea, prolonged cerbral depression after initial dose.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Resuscitation and intensive care facilities should be available when pyridoxalphosphate is used intravenously due to the risk of apnea and cerebral depression.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER PLAIN VITAMIN PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Other plain vitamin preparations
A11HA05
A11HA01
A11HA02
A11HA04
A11HA03
A11HA08

References

  1. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases,, Springer, 2006
  2. Baxter P., Pyridoxine or pyridoxal phosphate for intractable seizures?, Arch Dis Child, 2005, May;90(5), 441-2
  3. Wang HS et al, Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy, Arch Dis Child., 2005, May;90(5), 512-5

Changes

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