Benazepril
Generic name
Benazepril
Brand name
ATC Code
C09AA07
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Clearance
7-12 years: 0.35 l/h/kg
13-16 years: 0.17 l/h/kg
Adults: 0.13 l/h/kg
T½:
Children: 5 hours
Adults: 23 hours
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Hypertension |
|---|
|
Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
Dose adjustment is not required.GFR 30-50 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 24 uur. Then set the dose depending on the effect to the highest possible tolerated dose. The concentrations of creatinine and potassium must be checked within 2 weeks of commencing the treatment and then at least once a year, depending on the clinical condition of the patient.
GFR 10-30 ml/min/1.73 m2
25 percentage of single dose and dosing interval : 24 uur. Then set the dose depending on the effect to the highest possible tolerated dose. The concentrations of creatinine and potassium must be checked within 2 weeks of commencing the treatment and then at least once a year, depending on the clinical condition of the patient.
GFR < 10 ml/min/1.73 m2
Generalized recommendations cannot be given.Clinical consequences
ACE inhibitors lower the intraglomerular filtration pressure and reduce proteinuria. This means that they probably have a protective effect on renal function in the longer term. For this reason, the highest possible tolerated dose is often given in secondary care in cases of reduced renal function. When commencing an ACE inhibitor, the serum creatinine concentration can rise as a result of a decrease in the intraglomerular filtration pressure.
Patients on dialysis
25% of the normal dose each time and the interval between two doses: 24 hours. Then set the dose depending on the effect to the highest possible tolerated dose.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
ACE INHIBITORS, PLAIN
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| ACE inhibitors, plain | ||
|---|---|---|
| C09AA01 | ||
| C09AA02 | ||
| C09AA03 | ||
| C09AA04 | ||
| C09AA05 | ||
Reference
- Meda Pharma B.V., SmPC Cibacen (RVG 14080) 30-10-2014, www.geneesmiddeleninformatiebank.nl
Changes
Therapeutic Drug Monitoring
Overdose
