Tocophersolan (vitamin E-TPG)

Generic name
Tocophersolan (vitamin E-TPG)
Brand name
ATC Code
A11HA08
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Tocophersolan (vitamin E-TPG)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Absorption: As α-tocopherol, variable. Stored in fatty tissues. Metabolization: Tocophersolan is hydrolysed in the intestine. α-tocopherol is glucuronidated in the liver. Elimination: largely via the bile (75%), with the faeces.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Chronic cholestasis
  • Oral
    • Term neonate
      • 17 mg/kg/day in 1 dose

      • The dose must be adjusted depending on the vitamin E plasma concentration.
        17 mg/kg/day is equivalent to 0.34 ml/kg/day.

    • 1 month up to 18 years
      • 17 mg/kg/day in 1 dose

      • The dose must be adjusted depending on the vitamin E plasma concentration.
        17 mg/kg/day is equivalent to 0.34 ml/kg/day.
Supplementation in cystic fibrosis
  • Oral
    • 0 years up to 18 years
      • For persistent deficiencies 20 - 30 mg/kg/day in 1 dose

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications in children

Vedrop must not be used in premature infants.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER PLAIN VITAMIN PREPARATIONS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Other plain vitamin preparations
A11HA05
A11HA01
A11HA06
A11HA02
A11HA04
A11HA03

References

  1. Orphan Europe S.A.R.L, SPC Vedrop, www.emea.europa.eu, http://www.ema.europa.eu/humandocs/PDFs/EPAR/vedrop/emea-combined-h920nl.pdf (geraadpleegd 07 april 2010)
  2. Kneepkens CMF et al, Werkboek Kindergastro-Enterologie, VU Uitgeverij, 2002, 2e druk

Changes

Therapeutic Drug Monitoring


Overdose