5-hydroxytryptophan

Generic name
5-hydroxytryptophan
Brand name
ATC Code
N06AX01
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5-hydroxytryptophan

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information is present at this moment.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

GTP cyclohydrolase I deficiency (GTPCH); 6 pyruvoyl tetrahydropterin synthase deficiency (PTPS); dihydropteridine reductase deficiency (DHPR)
  • Oral
    • Term neonate
      • 1 - 2 mg/kg/day in 3 - 6 doses.

      • Start the dosage low and increase slowly (in steps of 1 mg/kg/day over several days or weeks)
        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using 5-hydroxytryptophan for this indication.

    • 1 month up to 2 years
      • 3 - 5 mg/kg/day in 3 - 6 doses.

      • Start the dosage low and increase slowly (in steps of 1 mg/kg/day over several days or weeks)
        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using 5-hydroxytryptophan for this indication.

         

    • ≥ 2 years
      • 6 - 9 mg/kg/day in 3 - 6 doses.

      • Start the dosage low and increase slowly (in steps of 1 mg/kg/day over several days or weeks)
        Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using 5-hydroxytryptophan for this indication.

         

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Gastrointestinal side effects

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIDEPRESSANTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Non-selective monoamine reuptake inhibitors
N06AA09
N06AA04
N06AA02
N06AA10
Selective serotonin reuptake inhibitors
N06AB04
N06AB10
N06AB03
N06AB08
N06AB06
Monoamine oxidase A inhibitors
N06AG02
Other antidepressants
N06AX12
N06AX21
N06AX11
N06AX11
N06AX16

References

  1. Blau N. et al, Physicians guide to the treatment and follow-up of metabolic diseases , Springer, 2006
  2. Blau N. et al, Physicians guide to the treatment and follow-up of metabolic diseases, Springer, 2006

Changes

Therapeutic Drug Monitoring


Overdose