Midodrine

Generic name
Midodrine
Brand name
ATC Code
C01CA17
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information is present at this moment.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Hypotension (incl. orthostatic)
  • Oral
    • 1 year up to 18 years
      • Initial dose: 2.5 - 5 mg/day in 1 - 2 doses.
      • Maintenance dose: depending on the blood pressure, increase as required to a maximum of 30 mg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (nephrologist) who has experience with using midodrine for this indication.

Renal impaiment in children > 3 months

Adjustment in renal impairment as specified:

GFR 50-80 ml/min/1.73 m2
Adjustment is not required
GFR 30-50 ml/min/1.73 m2
Adjustment is not required
GFR 10-30 ml/min/1.73 m2
Adjustment is not required
GFR < 10 ml/min/1.73 m2
Generalized recommendations cannot be given.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Adrenergic and dopaminergic agents
C01CA24
C01CA07
C01CA04
C01CA26
C01CA02
C01CA24
C01CA03
C01CA06
Phosphodiesterase inhibitors
C01CE02
Other cardiac stimulants
C01CX08

References

  1. Chen L et al, Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome, Circ J, 2011, 75(4), 927-931
  2. Qingyou Z, et al, The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope, J Pediatr, 2006, 149(6), 777-780

Changes

Therapeutic Drug Monitoring


Overdose