Levamisol
Generic name
Levamisol
Brand name
ATC Code
P02CE01
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
The following median (IQR) steady state population pharmacokinetic parameters were found in 38 children, 2-13 years of age (median 21 kg and 6,3 years), after oral doses of 2.5 mg/kg every other day (Kreeftmeijer-Vegter et al. 2015):
| Cmax | 438.3 (316,5 – 621.8) ng/ml |
| Tmax | 1.7 (1.3 – 2.0) hour |
| t½ | 2.6 (2.1 – 3.7) hour |
| Cl/F | 44 (RSE 8.5) l/hour/70 kg |
| Vd/F | 236 (RSE 13.3) l/70 kg |
IQR = interquartile range
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Steroid-sensitive nephrotic syndrome |
|---|
|
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Leucopenia and gastrointestinal upsets are described. Rare cases of cutaneous vasculitis have been described with levamisole therapy.(KDIGO guideline)
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Levamisole has been associated with agranulocytosis. Agranulocytosis is usually accompanied by flu-like symptoms (fever, shivering), but it can also be asymptomatic.Flulike symptoms can also occur without aranulocytosis.Patients and parents should contact their physician whenever flu-like symptoms occur, It's recommended to check the blood count every 4 weeks. (old SmPC Ergamisol)
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
ANTINEMATODAL AGENTS
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Benzimidazole derivatives | ||
|---|---|---|
| P02CA03 | ||
| P02CA01 | ||
| Tetrahydropyrimidine derivatives | ||
|---|---|---|
| P02CC01 | ||
| Avermectines | ||
|---|---|---|
| P02CF01 | ||
References
- Kreeftmeijer-Vegter AR, et al , Population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome. , Br J Clin Pharmacol. , 2015, 80(2), 242-252
- KDIGO , Clinical Practice Guideline for Glomerulonephritis, Kidney Int, 2012, Vol 2(Suppl 2), 139-274
- Jansen Cilag BV, SmPC Ergamisol (RVG 14850) 12 juni 2002 - license revoked by manufacturer
- Elmas, A. T., et al, Short- and long-term efficacy of levamisole in children with steroid-sensitive nephrotic syndrome, Int Urol Nephrol, 2013, 45 (4), 1047-55
- Gruppen, M. P., et al, A randomized clinical trial indicates that levamisole increases the time to relapse in children with steroid-sensitive idiopathic nephrotic syndrome, Kidney Int, 2018, 93 (2), 510-518
- Pravitsitthikul, N., et al, Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children., Cochrane Database Syst Rev, 2013, (10), Cd002290
- IBM Corporation. , 2020 Levamisole. In: In depth answers , Available from: www.micromedexsolutions.com Subscription required to view., [database in the internet]. Greenwood village (CO):
Changes
Therapeutic Drug Monitoring
Overdose
