Vancomycine oraal

Generic name
Vancomycine oraal
Brand name
ATC Code
A07AA09
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Vancomycine oraal

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

Vancomycin is usually not absorbed into the blood after oral administration. In the treatment of pseudomembranous colitis, resorption may occur after oral administration.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Clostridium difficile infection
  • Oral
    • ≥ 12 years
      [2]
      • 500 mg/day in 4 doses. for 10 days. .
        • In severe infections: 2000 mg / day in 4 doses for 10 days
        • in relapses: 500 mg / day in 4 doses for 10 days, then gradually reduce dose to 125 mg per day or a pulse course of at least 3 weeks 125-500 mg per day every 2-3 days.

        Do not open capsules before administration.

    • 1 month up to 12 years
      [3]
      • 40 mg/kg/day in 4 doses. Max: 2.000 mg/day.
    • Term neonate
      [3]
      • 40 mg/kg/day in 4 doses.
Enterocolitis as a result of staphylococci and pseudomembranous colitis
  • Oral
    • 1 month up to 18 years
      [1]
      • 40 mg/kg/day in 3 - 4 doses. Max: 2.000 mg/day.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Oral use is not indicated for the treatment of systemic infections.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

INTESTINAL ANTIINFECTIVES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Antibiotics
A07AA02
A07AA06
ANTIBIOTICS
A07AA02
A07AA06

References

  1. Rademaker, CMA et al, WKZ Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Eurocept International BV, SmPC Vancocin CP 250 mg (RVG 11984) 21-06-2021, www.geneesmiddeleninformatiebank.nl
  3. MIP Pharma GmbH, SmPC Vanco-saar® 500 mg / 1 g Vancomycinhydrochlorid, Pulver zur Herstellung einer Infusionslösung oder einer Lösung zum Einnehmen (39981.00.00), 05/2018

Changes

Therapeutic Drug Monitoring


Overdose