Albendazole

Generic name
Albendazole
Brand name
ATC Code
P02CA03
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Albendazole

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

The kinetics of albendazole sulfoxide in children are comparable to those in adults.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

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Treatment of hydatid cysts (echinococcosis)
  • Oral
    • 1 year up to 18 years
      [1] [2]
      • 15 mg/kg/day in 2 doses. Max: 800 mg/day.
      • Duration of treatment:

        Inoperable cysts: max 3 courses of 28 days.
        Pre-operative: 2 courses of 28 days with a 14-day interval between the courses before the operation.
        Perioperative and post-operative: 2 courses of 28 days with a 14-day interval between the courses after the operation.

      • Directions for administration:

        Take with a meal
Ascariasis, enterobiasis and hookworm infections
  • Oral
    • 1 year up to 18 years
      [2]
      • 15 mg/kg/dose, once only. Max: 400 mg/ doses.

      • In pinworm infections: repeat the dose after 14 days.
Trichuriasis
  • Oral
    • 1 year up to 18 years
      [2]
      • 15 mg/kg/day in 1 dose. Max: 400 mg/day.
      • Duration of treatment:

        3 days
Loiasis, strongyloidasis, ocular larva migrans, cysticercosis and neurocysticercosis
  • Oral
    • 1 year up to 18 years
      [2]
      • 15 mg/kg/day in 2 doses. Max: 800 mg/day.
      • Duration of treatment:

        Ocular larva migrans: 14 days
        cysticercosis and neurocysticercosis: 10 days
        loiasis: 21 days
        strongyloidasis: 7 days; 14 days in hyperinfection or immunosuppression

        In consultation with a paediatrician/infectiologist
Giardia lamblia
  • Oral
    • 1 year up to 18 years
      [2]
      • 15 mg/kg/day in 1 dose. Max: 400 mg/day.
      • Duration of treatment:

        5 days
Larva migrans profundus
  • Oral
    • 1 year up to 18 years
      [2]
      • 15 - 20 mg/kg/day in 2 doses. Max: 800 mg/day.
      • Duration of treatment:

        21 days (in consultation with a paediatrician/infectiologist)
Larva migrans cutanea
  • Oral
    • 1 year up to 18 years
      [2]
      • 20 mg/kg/day in 1 dose. Max: 400 mg/day.
      • Duration of treatment:

        5 days
Clonorchiasis
  • Oral
    • 1 year up to 18 years
      [2]
      • 20 mg/kg/day in 2 doses. Max: 800 mg/day.
      • Duration of treatment:

        7 days (in consultation with a paediatrician/infectiologist)

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTINEMATODAL AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Benzimidazole derivatives
P02CA01
Tetrahydropyrimidine derivatives
P02CC01
Imidazothiazole derivatives
P02CE01
Avermectines
P02CF01

References

  1. Medcor Pharmaceuticals BV, SmPC Eskazole (RVG 15437) 05-08-2013, www.geneesmiddeleninformatiebank.nl
  2. Nederlandse Vereniging voor Parasitologie, Therapierichtlijn parasitaire infecties, 2020

Changes

Therapeutic Drug Monitoring


Overdose