Artesunate

Generic name
Artesunate
Brand name
ATC Code
P01BE03
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Artesunate

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information is present at this moment.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Severe tropical malaria (P. falciparum)
  • Intravenous
    • < 20 kg
      [1]
      • 3 mg/kg/dose at 0, 12 and 24 hours, then once daily..

      • Intravenous administration for at least 24 hours; after that a switch can be made to oral therapy.

    • ≥ 20 kg
      [1]
      • 2.4 mg/kg/dose at 0, 12 and 24 hours, then once daily..

      • Intravenous administration for at least 24 hours; after that a switch can be made to oral therapy.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Reversible blood count abnormalities: delayed or persistent haemolytic anemia (increased risk in hyperparasitemia and in young children (at 6 months–10 years; approx. 7%).

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Since haemolysis and anemia can still occur 14–28 days after treatment with artesunate, monitor the hemoglobin level for a further 4 weeks after treatment.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIMALARIALS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Aminoquinolines
P01BA01
P01BA02
Biguanides
P01BB01
Methanolquinolines
P01BC02
P01BC01
Diaminopyrimidines
P01BD01
Artemisinin and derivatives, combinations
P01BF01

Reference

  1. WHO, Guidelines for the treatment of malaria., www.who.int, 2015, 3rd edition

Changes

Therapeutic Drug Monitoring


Overdose