Pegaspargase

Generic name
Pegaspargase
Brand name
ATC Code
L01XX24
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Pegaspargase

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

There is no specific data for children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Acute lymphatic leukaemia
  • Intravenous
    • 0 years up to 18 years
      [1]

      • The dosage and dosing frequency of oncological agents depend on the condition and are very much subject to new insights. Oncological drugs are often used in combinations. For this reason, please refer to the detailed treatment protocols (see www.skion.nl). Indicative dosages have been stated by the manufacturer:

        < 0.6 m² BSA: 82.5 U/kg once every 14 days
        > 0.6 m² BSA: 2500 U/m² BSA once every 14 days

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER ANTINEOPLASTIC AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Methylhydrazines
L01XB01
PROTEINEKINASEREMMERS
L01XE06
L01XE01
Other antineoplastic agents
L01XX02
L01XX05

Reference

  1. Baxalta Innovations GmbH, SmPC Oncaspar (EU/1/15/1070/001) 29-01-2016, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose