Deferiprone

Generic name
Deferiprone
Brand name
ATC Code
V03AC02
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Deferiprone

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information available about the pharmacokinetic parameters in children

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Iron accumulation
  • Oral
    • 6 years up to 18 years
      [1]
      • 75 mg/kg/day in 3 doses. Max: 100 mg/kg/day.

      • Use when treatment with other chelation therapy is contraindicated or inadequate.

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Neurological disorders (episodes of hypotonia, instability, inability to walk, and hypertonia with inability of limb movement) have been reported in children with standard dose therapy. Cerebellar symptoms, diplopia, lateral nystagmus, psychomotor slowdown, hand movements and axial hypotonia have been reported in children with therapy 2.5 x standard maximum dose. Arthropathy and diarrhoea were observered more frequently in children than in adults.

[SmPC Ferriprox]

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Neurological disorders have been observed in children. If neurological disorders are observed, therapy should be stopped.

[SmPC Ferriprox]

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ALL OTHER THERAPEUTIC PRODUCTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Antidotes
V03AB15
V03AB14
Iron chelating agents
V03AC03
V03AC01
Detoxifying agents for antineoplastic treatment
V03AF03
V03AF01
V03AF07
Drugs for treatment of hypoglycemia
V03AH01
DETOXIFYING AGENTS FOR ANTINEOPLASTIC TREATMENT
V03AF03
V03AF01
V03AF07

Reference

  1. Apotex Europe B.V., SPC Ferriprox (EU/1/99/108/001) 10-08-2017, www.ema.europa.eu

Changes

Therapeutic Drug Monitoring


Overdose