Tetanus immunoglobulin

Generic name
Tetanus immunoglobulin
Brand name
ATC Code
J06BB02
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Tetanus immunoglobulin

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Tetanus Post-Exposure Prophylaxis (PEP) if not or incompletely vaccinated according to (Dutch) National Vaccination Programme
  • Intramuscular
    • 0 years up to 18 years
      [3]
      • 250 - 500 IU/dose, once only.
      • Directions for administration:

        Inject slowly, deep into the muscle. The preparation should preferably be brought to body temperature before administering it.

      • If there are severe injuries, if the injury occurred > 24 hours ago and in adipose adults: 500 IU/dose as a one-time dose

        Fully vaccinated are:

        • Children up to 5 months:

          • if the mother has received maternal whooping cough vaccination (DKT) during pregnancy AND

          • there are no risk factors for insufficient transfer of antibodies from mother to child AND

          • the mother herself has ever been fully vaccinated against tetanus (according to RVP or equivalent).

        • Children 5 - 12 months who:

          • Have had primary DKTP vaccinations from RVP according to schedule: 3 doses of the 2-3-5-11 schedule or after maternal whooping cough vaccination 2 doses of the 3-5-11 schedule.

          • If necessary, in consultation with the JGZ, bring forward the  DKTP-HiB-HepB booster vaccination from the RVP, at least 5 months after the last dose of the primary series.

        • Children > 12 months who have received

          • Have received primary DKTP vaccinations from RVP according to schedule

          • If necessary, missed RVP vaccinations at 4 and 9 years of age will be caught up on after consultation with the JGZ.

        Post-exposure prophylaxis with tetanus immunoglobulin would seem to be useful up to 3 weeks after the wound.

        ...read more
Prophylaxis for injuries: Immuno-incompetent people, irrespective of the vaccination status against tetanus
  • Intramuscular
    • 0 years up to 18 years
      [3]
      • 250 IU/dose, once only. in combination with 1 dosis of tetanus toxoid (DTP, young children DPTP) in fully vaccinated patients. If not or incompletely vaccinated, catch up on the missing vaccinations. .

      • Post-exposure prophylaxis with tetanus immunoglobulin would seem to be useful up to 3 weeks after the wound.
Clinically manifest tetanus
  • Intramuscular
    • 1 month up to 18 years
      [2]
      • 3.000 IU/day in 1 dose
      • Duration of treatment:

        2 days

      • Directions for administration:

        Inject slowly, deep into the muscle. The preparation should preferably be brought to body temperature before administering it.

      • Active immunization after recovery.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

IMMUNOGLOBULINS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Immunoglobulins, normal human
J06BA02
J06BA01
IMMUNOGLOBULINS, NORMAL HUMAN
J06BA02
J06BA01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen Formularium voor Kinderen, 2009
  2. Gezondheidsraad, Immunisatie tegen tetanus bij verwonding, Den Haag, 2003
  3. LCI, Richtlijn Tetanus, www.lci.rivm.nl, Vaststelling LCI 29 januar 2019, update PEP kinderen 5 aug 2020

Changes

Therapeutic Drug Monitoring


Overdose