Fomepizole

Generic name
Fomepizole
Brand name
ATC Code
VO3AB34
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Fomepizole

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Acute ethylene glycol intoxication
  • Intravenous
    • 1 month up to 18 years
      [1]

      • Start:15 mg/kg/dose

        Subsequent doses:
        second dose (12 hours after starting): 10 mg/kg/dose
        third dose (24 hours after starting): 10 mg/kg/dose
        fourth dose (36 hours after starting): 10 mg/kg/dose
        fifth dose (48 hours after starting): 7.5–15 mg/kg/dose
        sixth dose (60 hours after starting): 5-15 mg/kg/dose
        Administer over 30-45 minutes.

        Until the ethylene glycol levels have dropped to below 0.2 g/l (3.2 mmol/l).
        The number of maintenance doses and the dosage after 48 hours will depend on the initial concentration and the progression of the ethylene glycol levels over time. In general, 4 to 5 maintenance doses are recommended for initial ethylene glycol levels of between 3 and 6 g/l (48 to 96 mmol/l) and 1 to 3 maintenance doses are recommended for initial ethylene glycol levels of between 0.35 and 1.5 g/l (5.6 to 24 mmol/l)

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Reference

  1. Eusa Pharma, SPC Fomepizole (RVG 26970) 21/07/11, www.cbg-meb.nl, Geraadpleegd 23 okt 2014

Changes

Therapeutic Drug Monitoring


Overdose