Sevoflurane

Generic name
Sevoflurane
Brand name
ATC Code
N01AB08
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Sevoflurane

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Inhalation anaesthesia
  • Inhalation
    • Full-term neonates and children 0 months up to 18 years
      [2]

      • The dosage is determined for the individual;

        Minimum alveolar concentration:
        0-1 months: 3.3% (in 100% oxygen)
        1-6 months: 3.0% (in 100% oxygen)
        6 months-3 years: 2.8% (in 100% oxygen); 2.0% (in 60% nitrous oxide and 40% oxygen)
        3-12 years: 2.5% (in 100% oxygen)

         

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Delirium on awakening occurs 2-3 times more frequently in children under 6 years of age than in adults.
Convulsions have occurred in particular in children from 2 months. Cases of ventricular arrhythmia have been reported in children with Pompe disease.
 

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Limiting the depth of anaesthesia is recommended in children with an increased risk of convulsions. The sevoflurane dose can be optimized by means of an EEG and can be checked for development of convulsive activity.
After administration of sevoflurane has stopped, the patient should be ventilated with 100% oxygen until they are fully awake.
Caution is recommended where there is an increased risk of lengthening of the QTc interval, such as in cases of long QT interval syndrome and in elderly patients with cardiovascular risk factors. Caution is also recommended where there is an increased risk of convulsions, in sleep apnoea (as this may worsen) and in myasthenia gravis (due to the susceptibility to respiratory depression).

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANESTHETICS, GENERAL

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Halogenated hydrocarbons
N01AB06
Other general anesthetics
N01AX14
N01AX10

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor kinderen, 2007
  2. Piramal Critical Care B.V. , SmPC Sevoflurane 100% (RVG 106958) 21-06-2023, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose