Thiamine (vitamin B1)

Generic name
Thiamine (vitamin B1)
Brand name
ATC Code
A11DA01
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Thiamine (vitamin B1)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No studies have been carried out into the pharmacokinetic parameters of thiamine in children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Vitamin B1 deficiency
  • Oral
    • 1 month up to 18 years
      [1]
      • 12.5 - 100 mg/day in 2 - 3 doses.
  • Intravenous
    • 1 month up to 18 years
      [1]
      • 25 - 100 mg/day in 2 - 3 doses. infuse over 15 minutes.

      • Can possibly be administered intramuscularly or subcutaneously
Thiamine responsive Maple syrup urine disease (MSUD), lactic acidosis resulting from PDH deficiency or complex I of the respiratory chain
  • Oral
    • 1 month up to 18 years
      [2] [3] [4]
      • 50 - 200 mg/day in 1 dose

      • The exact dose has not been determined. Widely varying doses have been used in studies, from 10 to 2400 mg/day.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

References

  1. Fattal-Valevski A, et al , Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula., Pediatrics., 2005, Feb;115(2), e233-8
  2. Naito E, et al, Thiamine-responsive lactic acidaemia: role of pyruvate dehydrogenase complex., Eur J Pediatr. , 1998, Aug;157(8), 648-52
  3. Duran M, et al, Thiamine-responsive inborn errors of metabolism, J Inherit Metab Dis, 1985, 8 Suppl 1:, 70-5
  4. Elsas LJ, et al, The role of thiamin in maple syrup urine disease, Ann N Y Acad Sci, 1982, 378, 404-21

Changes

Therapeutic Drug Monitoring


Overdose